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KMID : 0043320040270111099
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Archives of Pharmacal Research
2004 Volume.27 No. 11 p.1099 ~ p.1105
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Synthesis and Biological Activity of Benzoxazole Containing Thiazolidinedione Derivatives
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Jeon Ra-Ok
Park So-Yeon
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Abstract
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The peroxisome proliferator-activated receptors (PPARs) are a primary regulator of lipid metabolism. Potency for activation of PPAR, one of a subfamily of PPARs, particularly mirrors glucose lowering activity. We prepared thiazolidinediones featuring benzoxazole moiety for subtype selective PPAR activators. 5-[4-[2-(Benzoxazol-2-yl-alkylamino)ethoxy]benzyl]thiazolidine-2,4-diones have been prepared by Mitsunobu reaction of benzoxazolylalkylaminoethanol 8 and hydroxybenzylthiazolidinedione 6 and their activities were evaluated. Most compounds tested were identified as potent PPAR agonists.
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KEYWORD
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xazole, Thiazolidinedione, PPAR
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